Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails, hair, and mucous membranes. It is not an actual lichen, and is only named that because it looks like one. It is characterized by polygonal, flat-topped, violaceous papules and plaques with overlying, reticulated, fine white scale, commonly affecting dorsal hands, flexural wrists and forearms, trunk, anterior lower legs and oral mucosa.
Lichen planus (LP) 是一種持久的發炎性疾病,主要影響中年成年人。它可出現在皮膚或黏膜上,如口腔、陰道、食道、喉部和眼瞼。根據皮疹的外觀與分布位置,LP 有不同的型態。研究顯示,某些類型的 LP,例如累及食道或眼睛的,可能難以充分診斷。部分形式的 LP,如口腔內的肥厚型與糜爛型,往往特別造成負擔且持續時間較長。藥物或接觸特定物質等其他因素,也可能誘發類似的皮疹。 Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. LP can involve the skin or mucous membranes including the oral, vulvovaginal, esophageal, laryngeal, and conjunctival mucosa. It has different variants based on the morphology of the lesions and the site of involvement. The literature suggests that certain presentations of the disease such as esophageal or ophthalmological involvement are underdiagnosed. The burden of the disease is higher in some variants including hypertrophic LP and erosive oral LP, which may have a more chronic pattern. LP can significantly affect the quality of life of patients as well. Drugs or contact allergens can cause lichenoid reactions as the main differential diagnosis of LP.
Lichen planus 是一種以紫色、平頂的腫塊與斑塊為特徵的皮膚疾病,常伴隨劇烈搔癢。這些皮膚病變可能相當痛苦,尤其當它們嚴重累及口腔或生殖器時。嚴重時, oral lichen planus 甚至可能提升皮膚癌的風險。此疾病亦可波及頭皮與指甲。雖然大多數病例的成因尚未明確,但部分病例可能與特定藥物或C型肝炎感染有關。治療方面,局部病例通常使用效力較強的藥膏,而較廣泛的病變則可能需要口服類固醇。 Lichen planus is a skin condition marked by purplish, flat-topped bumps and patches that can cause intense itching. These skin lesions can be distressing, especially when they affect the mouth or genitals severely. In severe cases, oral lichen planus may even increase the risk of developing a type of skin cancer. It can also affect the scalp and nails. While the cause of most cases is unknown, some may be triggered by certain medications or hepatitis C infection. Treatment typically involves strong creams for localized cases and oral steroids for more widespread ones.
Lichen planus 是免疫系統引起的發炎狀況,會在皮膚和黏膜上留下明顯的病變。它影響約 5% 的成年人,女性較常見,通常在中年左右發病。高達 77% 的患者會出現口腔受累,最常影響內頰。雖然有些人可能沒有任何症狀,但也有人會感到疼痛,且對某些食物(如酸性或辛辣食物)或牙膏感到不適。 Lichen planus is an immune-mediated inflammatory condition leading to characteristic lesions on skin and mucous membranes. It presents in up to 5% of the general adult population with a female predilection (2:1); the onset is most commonly in middle age. Up to 77% of patients with lichen planus have oral disease, with buccal mucosa the most common subsite. The oral lesions may be asymptomatic, although a subset of patients have pain and difficulty tolerating certain foods (e.g., acidic, spicy) and toothpaste.
確診皮膚扁平苔蘚時,可進行皮膚活檢。直接免疫螢光 (DIF) 可用於大皰性病變的患者,以協助區分本病與自體免疫性水皰性大皰性疾病。